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PMID: 2542605 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Antigen-presenting liposomes are effective in treatment of recurrent herpes simplex virus genitalis in guinea pigs.

Journal of virology ·Vol. 63 ·No. 7 ·1989-07-00 ·Pages 2951-8

Ho RJ, Burke RL, Merigan TC

Abstract

The therapeutic and immunologic effects of a liposome preparation containing both a macrophage activator, muramyl-tripeptide-phosphatidylethanolamine, and a recombinant antigen, glycoprotein D of herpes simplex virus type 1, have been investigated. This preparation was tested in vitro for the ability to stimulate peripheral blood lymphocytes and in vivo for the control of recurrent herpes genitalis in guinea pigs. Our results show that the liposome-antigen-adjuvant preparation is capable of enhancing antigen-specific lymphocyte stimulation, which may be related to the observed 75% suppression of the frequency and severity of reactivation of recurrent herpes simplex virus type 2 genitalis compared with that of placebo controls.

MeSH Terms
Acetylmuramyl-Alanyl-Isoglutamine/administration & dosage,analogs & derivatives,therapeutic use Animals Antigens, Viral/administration & dosage Antiviral Agents/administration & dosage Female Guinea Pigs Herpes Genitalis/therapy Immunotherapy Liposomes Phosphatidylcholines Phosphatidylethanolamines/administration & dosage,therapeutic use Recombinant Proteins/administration & dosage Simplexvirus/immunology Viral Envelope Proteins/administration & dosage
Chemicals
Antigens, Viral Antiviral Agents Liposomes Phosphatidylcholines Phosphatidylethanolamines Recombinant Proteins Viral Envelope Proteins glycoprotein D, Human herpesvirus 1 mifamurtide Acetylmuramyl-Alanyl-Isoglutamine 1,2-oleoylphosphatidylcholine
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Ho R J
Department of Medicine, Stanford University School of Medicine, California 94305.
Burke R L
Merigan T C
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32 references, click to expand
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.63.7.2951-2958.1989
Published
1989-07-00
Pages
2951-8
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC250849
Subset
IM
Grants
NIAID NIH HHS · AI 0569-25 · United States
NIAID NIH HHS · AI 07089-09 · United States
External Links
PubMed source DOI: 10.1128/JVI.63.7.2951-2958.1989 PMC Full Text View journal details
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