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题目:: ID1 is a functional marker for intestinal stem and progenitor cells required for normal response to injury.
作者:: Zhang(Ning),Yantiss(Rhonda K),Nam(Hyung-Song),Chin(Yvette),Zhou(Xi Kathy),Scherl(Ellen J),Bosworth(Brian P),Subbaramaiah(Kotha),Dannenberg(Andrew J),Benezra(Robert)
状态:: 发布时间2014-11-24 , 更新时间 2016-10-25
期刊:: Stem Cell Reports
摘要:: LGR5 and BMI1 mark intestinal stem cells in crypt base columnar cells and +4 position cells, respectively, but characterization of functional markers in these cell populations is limited. ID1 maintains the stem cell potential of embryonic, neural, and long-term repopulating hematopoietic stem cells. Here, we show in both human and mouse intestine that ID1 is expressed in cycling columnar cells, +4 position cells, and transit-amplifying cells in the crypt. Lineage tracing revealed ID1+ cells to be self-renewing, multipotent stem/progenitor cells that are responsible for the long-term renewal of the intestinal epithelium. Single ID1+ cells can generate long-lived organoids resembling mature intestinal epithelium. Complete knockout of Id1 or selective deletion of Id1 in intestinal epithelium or in LGR5+ stem cells sensitizes mice to chemical-induced colon injury. These experiments identify ID1 as a marker for intestinal stem/progenitor cells and demonstrate a role for ID1 in maintaining the potential for repair in response to colonic injury.
语言:: eng
DOI:

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