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题目:: Neogenin expression is inversely associated with breast cancer grade in ex vivo.
作者:: Xing(Wanying),Li(Qiang),Cao(Rangjuan),Xu(Zheli)
状态:: 发布时间2014-12-03 , 更新时间 2015-11-19
期刊:: World J Surg Oncol
摘要:: Neogenin is closely related to the human tumor suppressor gene deleted in colorectal cancer and plays a role in mammary morphogenesis. This study aimed to assess neogenin expression in breast cancer for any clinically significant association.,A total of 54 breast cancer patients who underwent modified radical mastectomy were enrolled for immunohistochemical and quantitative real-time PCR analysis of neogenin expression in their cancerous breast tissues in comparison to matching distant non-cancerous tissues.,The data showed that the neogenin protein was either strongly or moderately expressed in the cytoplasm of the distant non-cancerous cells. In contrast, neogenin protein was either weakly or not expressed in the cytoplasm of 51/54 (94.4%) breast cancer cells, among which 13 breast cancer cases did not express neogenin protein at all (13/54, 24.1%). Similarly, levels of neogenin mRNA were significantly lower in breast cancer tissues than that of the matched distant non-cancerous tissues (51/54, 94.4%). Neogenin expression was inversely associated with breast cancer grade; that is, grade III breast cancer expressed much less neogenin than grade I-II (P<0.05).,This study indicates that neogenin expression in breast cancer tissues is inversely associated with tumor grade.
语言:: eng
DOI:

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