| GeneLibs

题目:: Reprogramming of prostate cancer cells--technical challenges.
作者:: Borges(Gisely T),Vêncio(Eneida F),Vêncio(Ricardo Z N),Vessella(Robert L),Ware(Carol B),Liu(Alvin Y)
状态:: 发布时间2014-11-18 , 更新时间 2014-11-18
期刊:: Curr Urol Rep
摘要:: Prostate cancer progression is characterized by tumor dedifferentiation. Cancer cells of less differentiated tumors have a gene expression/transcriptome more similar to that of stem cells. In dedifferentiation, cancer cells may follow a specific program of gene expression changes to a stem-like state. In order to treat cancer effectively, the stem-like cancer cells and cancer differentiation pathway need to be identified and studied. Due to the very low abundance of stem-like cancer cells, their isolation from fresh human tumors is technically challenging. Induced pluripotent stem cell technology can reprogram differentiated cells into stem-like, and this may be a tool to generate sufficient stem-like cancer cells.
语言:: eng
DOI:: 10.1007/s11934-014-0468-4

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