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题目:: Cell surface N-glycans influence the level of functional E-cadherin at the cell-cell border.
作者:: Hall(M Kristen),Weidner(Douglas A),Dayal(Sahil),Schwalbe(Ruth A)
状态:: 发布时间2014-11-07 , 更新时间 2014-11-10
期刊:: FEBS Open Bio
摘要:: E-cadherin is crucial for adhesion of cells to each other and thereby development and maintenance of tissue. While it is has been established that N-glycans inside the cell impact the level of E-cadherin at the cell surface of epithelial-derived cells, it is unclear whether N-glycans outside the cell control the clustering of E-cadherin at the cell-cell border. Here, we demonstrate reduction of N-glycans at the cell surface weakened the recruitment and retention of E-cadherin at the cell-cell border, and consequently reduced the strength of cell-cell interactions. We conclude that N-glycans at the cell surface are tightly linked to the placement of E-cadherin at the cell-cell border and thereby control E-cadherin mediated cell-cell adhesion.
语言:: eng
DOI:

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