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PMID: 2537694 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

The role of calcium channels and serotonin (5-HT2) receptors for tumour cell lodgement in the liver.

Clinical & experimental metastasis ·Vol. 7 ·No. 2 ·1989-00-00 ·Pages 169-74

Skolnik G, Bagge U, Blomqvist G, Djärv L, Ahlman H

Abstract

The effect of blockade of calcium channels and/or 5-HT receptors on the hepatic lodgement of intraportally injected fibrosarcoma cells was studied in rats. The calcium channel blocker verapamil and the 5-HT2 antagonist ketanserin each had a significant lodgement reducing effect. The pure 5-HT2 antagonist R 56413 was most effective and dose-dependent in its tumour cell lodgement reducing effect. At the highest dose tested (2.5 mg/kg body weight) R 56413 was as effective as thrombocytopenia, indicating that 5-HT is the most important platelet-released product that influences tumour cell lodgement.

MeSH Terms
Animals Blood Platelets/physiology Calcium Channels/physiology Ketanserin/pharmacology Liver Neoplasms, Experimental/pathology Male Neoplasm Metastasis Piperidines/pharmacology Rats Receptors, Serotonin/physiology Verapamil/pharmacology
Chemicals
Calcium Channels Piperidines Receptors, Serotonin seganserin Ketanserin Verapamil
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Skolnik G
Department of Surgery I, University of Göteborg, Sweden.
Bagge U
Blomqvist G
Djärv L
Ahlman H
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Article Info
Journal
Clinical & experimental metastasis
Abbr.
Clin Exp Metastasis
ISSN
0262-0898
DOI
10.1007/BF01787021
Published
1989-00-00
Pages
169-74
Language
English
Region
Netherlands
NLM ID
8409970
Subset
IM
External Links
PubMed source DOI: 10.1007/BF01787021 View journal details
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