Real-time liquid biopsy: circulating tumor cells versus circulating tumor DNA.

Annals of translational medicine ·Vol. 1 ·No. 2 ·2013-07-00 ·Pages 18

Alix-Panabières C, Pantel K

Abstract

Liquid biopsy is a new diagnostic concept, i.e., analysis of therapeutic targets and drug resistance-conferring gene mutations on circulating tumor cells and cell-free circulating tumor DNA released into the peripheral blood from metastatic deposits. Here, we discuss current challenges and future perspectives of the liquid biopsy concept in clinical oncology. We postulate that this concept will contribute to a better understanding and clinical management of drug resistance in cancer patients.

Keywords

Cancer biomarkers blood circulating tumor DNA (ctDNA) circulating tumor cells (CTCs) therapy

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Alix-Panabières Catherine

1 University Medical Centre, Saint-Eloi Hospital, Institute of Research in Biotherapy, Department of Cell and Tissue Biopathology of Tumors, Laboratory of Rare Human Circulating Cells, Montpellier, France ; 2 University Institute of Clinical Research UM1-EA2415-Epidemiology, Biostatistics & Public Health, Montpellier, France ; 3 Department of Tumor Biology, Centre of Experimental Medicine, University Medical Centre Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany.

Pantel Klaus

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12 references, click to expand

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Article Info

Journal

Annals of translational medicine

Abbr.

Ann Transl Med

ISSN

2305-5839

DOI

10.3978/j.issn.2305-5839.2013.06.02

Published

2013-07-00

Pages

Language

English

Region

China

NLM ID

101617978

PMCID

PMC4200637

External Links

PubMed source DOI: 10.3978/j.issn.2305-5839.2013.06.02 PMC Full Text

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