Lymphokine regulation of CD45R expression on human T cell clones.
Whether the expression of higher molecular weight isoforms of the T-200 complex represents different lineages of T cells and/or a sequential stage of the differential pathway of T cells has been unclear. Understanding T cell expression of higher molecular weight isoforms of the T-200 complex (CD45R) may be important because of their association with regulation of immune responses. By direct single cell cloning, we observed a number of long-term T cell clones that expressed CD45RA (2H4). CD45RA expression could be further regulated by ionomycin or the cytokines IL-1 and IL-6, but not IL-2, IL-4, or IFN-gamma. These results indicate that CD45RA expression may define T cell lineages of activated T cells partially controlled by the cytokines IL-1 and IL-6. Further, these results may associate regulatory actions of IL-1 and IL-6 with their ability to increase CD45RA expression in subpopulations of human T cells.
15 references, click to expand
-
Structural studies of murine lymphocyte surface IgD.J Immunol. 1980 May;124(5):2082-8 PMID: 6767780
-
Molecular interactions, T-cell subsets and a role of the CD4/CD8:p56lck complex in human T-cell activation.Immunol Rev. 1989 Oct;111:225-66 PMID: 2534114
-
Evidence from cDNA clones that the rat leukocyte-common antigen (T200) spans the lipid bilayer and contains a cytoplasmic domain of 80,000 Mr.Cell. 1985 May;41(1):83-93 PMID: 3158393
-
Identification of the sequence required for expression of the 2H4 epitope on the human leukocyte common antigens.J Exp Med. 1987 Nov 1;166(5):1567-72 PMID: 2445891
-
The subdivision of the T4 (CD4) subset on the basis of the differential expression of L-C/T200 antigens.J Exp Med. 1987 Dec 1;166(6):1758-73 PMID: 2960772
-
Human memory T lymphocytes express increased levels of three cell adhesion molecules (LFA-3, CD2, and LFA-1) and three other molecules (UCHL1, CDw29, and Pgp-1) and have enhanced IFN-gamma production.J Immunol. 1988 Mar 1;140(5):1401-7 PMID: 2894392
-
Loss of CD45R and gain of UCHL1 reactivity is a feature of primed T cells.J Immunol. 1988 Apr 1;140(7):2171-8 PMID: 2965180
-
The CD4 receptor is complexed in detergent lysates to a protein-tyrosine kinase (pp58) from human T lymphocytes.Proc Natl Acad Sci U S A. 1988 Jul;85(14):5190-4 PMID: 2455897
-
The functionally distinct subpopulations of human CD4+ helper/inducer T lymphocytes defined by anti-CD45R antibodies derive sequentially from a differentiation pathway that is regulated by activation-dependent post-thymic differentiation.J Immunol. 1988 Sep 1;141(5):1464-70 PMID: 2970504
-
The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck.Cell. 1988 Oct 21;55(2):301-8 PMID: 3262426
-
CD45 regulates signal transduction and lymphocyte activation by specific association with receptor molecules on T or B cells.Proc Natl Acad Sci U S A. 1988 Nov;85(22):8628-32 PMID: 2973067
-
Demonstration that the leukocyte common antigen CD45 is a protein tyrosine phosphatase.Biochemistry. 1988 Nov 29;27(24):8695-701 PMID: 2853967
-
The CD4 and CD8 antigens are coupled to a protein-tyrosine kinase (p56lck) that phosphorylates the CD3 complex.Proc Natl Acad Sci U S A. 1989 May;86(9):3277-81 PMID: 2470098
-
Multiple actions of interleukin 6 within a cytokine network.Immunol Today. 1988 May;9(5):137-9 PMID: 3076767
-
The isolation and characterization of the human suppressor inducer T cell subset.J Immunol. 1985 Mar;134(3):1508-15 PMID: 3155770
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