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题目:: Thymic nurse cells: possible sites of T-cell selection.
作者:: Kyewski(B A)
状态:: 发布时间2014-10-08 , 更新时间 2014-10-08
期刊:: Immunol Today
摘要:: The precise role of the thymic microenvironment in induction and selection of the T-cell repertoire, a matter of considerable interest to immunologists, has been difficult to define. Direct cell-cell interactions between thymocytes and distinct stromal cells are an important component of this thymic microenvironment. Thymic epithelial cells, in particular, have been suspected to select immature T cells for self MHC-specificity via direct cell-cell contact. Here, Bruno Kyewski discusses the type of epithelial cells known as thymic nurse cells and their remarkable association with the thymocytes which are completely enclosed within them.
语言:: eng
DOI:: 10.1016/0167-5699(86)90030-7

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