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PMID: 2524381 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

A novel, inducible and T cell-specific enhancer located at the 3' end of the T cell receptor alpha locus.

The EMBO journal ·Vol. 8 ·No. 3 ·1989-03-00 ·Pages 729-33

Winoto A, Baltimore D

Abstract

A novel, powerful and T-cell-specific enhancer element has been identified at 3 kb 3' of the mouse T cell receptor (TCR) C alpha (constant) gene. A previous report of an intragenic enhancer could not be confirmed. The unique organization of the TCR alpha locus and transcriptional data of the alpha promoter suggest that this enhancer can act over 69 kb. This feature of the alpha enhancer may lead to deregulation of c-myc and other oncogenes translocated to this locus in many T cell leukemias, resulting in T cell neoplasia. The enhancer was localized to 230 bp of DNA and has been found to be inducible in an immature T lymphoid cell line. Deletions localizing critical regions and T-cell-specific binding proteins of this enhancer are described.

MeSH Terms
Animals Base Sequence Cell Line DNA/genetics DNA-Binding Proteins/metabolism Enhancer Elements, Genetic Introns Mice Molecular Sequence Data Receptors, Antigen, T-Cell/genetics Receptors, Antigen, T-Cell, alpha-beta T-Lymphocytes/immunology,metabolism
Chemicals
DNA-Binding Proteins Receptors, Antigen, T-Cell Receptors, Antigen, T-Cell, alpha-beta DNA
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Winoto A
Whitehead Institute for Biomedical Research, Cambridge, MA 02142.
Baltimore D
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Article Info
Journal
The EMBO journal
Abbr.
EMBO J
ISSN
0261-4189
Published
1989-03-00
Pages
729-33
Language
English
Region
England
NLM ID
8208664
PMCID
PMC400868
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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