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题目:: Adenine uptake cells in the rat kidney with remarks on the expression of Ia antigen.
作者:: Osogoe(B),Fukumoto(T),Seno(S)
状态:: 发布时间1990-02-13 , 更新时间 2013-11-21
期刊:: Arch Histol Cytol
摘要:: The patterns of [14C] adenine ([14C]A) incorporation into DNA by proliferative cells in the kidney were studied by the autoradiographic technique. It was revealed that, after 3 daily injections of [14C]A (1 microCi/g body weight each), a portion of the glomerular cells and a few fibroblastoid cells in the cortical intexstitium incorporated [14C]A into DNA to a remarkable extent. Such cells also incorporated [3H]thymidine, but to a lesser extent. The cells which incorporate [14C]A to a particularly great extent (adenine uptake cells) also occur in other tissues. Such cells are confined to a few cell types of either the macrophage or fibroblast or reticulum cell lines. This fact suggests that the adenine uptake cells observed in the glomerulus are also of a similar cell line and most likely mesangial cells. By immunohistochemical examination for Ia antigen, adenine uptake cells are divided into Ia-positive and Ia-negative types. The present examination showed that the major portion of adenine uptake cells in the glomerulus are Ia-negative, and it is suggested that these cells are analogous to the Ia-negative macrophages in the lung. This suggestion is supported by the fact that, in the glomerulus, colloidal carbon uptake cells (macrophage-like cells) are present in fairly large numbers. The Ia-positive cells seem to be of the same cell line as the adenine uptake cells that express Ia antigen in other tissues, such as septal fibroblasts in the lung.
语言:: eng
DOI:

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