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PMID: 25137456 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

The self-obsession of T cells: how TCR signaling thresholds affect fate 'decisions' and effector function.

Nature immunology ·Vol. 15 ·No. 9 ·2014-09-00 ·Pages 815-23

Hogquist KA, Jameson SC

Abstract

Self-reactivity was once seen as a potential characteristic of T cells that was eliminated by clonal selection to protect the host from autoimmune pathology. It is now understood that the T cell repertoire is in fact broadly self-reactive, even self-centered. The strength with which a T cell reacts to self ligands and the environmental context in which this reaction occurs influence almost every aspect of T cell biology, from development to differentiation to effector function. Here we highlight recent advances and discoveries that relate to T cell self-reactivity, with a particular emphasis on T cell antigen receptor (TCR) signaling thresholds.

MeSH Terms
Autoimmunity/immunology Clonal Deletion/immunology Humans Receptors, Antigen, T-Cell/immunology Signal Transduction/immunology T-Lymphocytes/immunology
Chemicals
Receptors, Antigen, T-Cell
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Hogquist Kristin A
Center for Immunology and Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, USA.
Jameson Stephen C
Center for Immunology and Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, USA.
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Article Info
Journal
Nature immunology
Abbr.
Nat Immunol
ISSN
1529-2916
DOI
10.1038/ni.2938
Published
2014-09-00
Pages
815-23
Language
English
Region
United States
NLM ID
100941354
PMCID
PMC4348363
Subset
IM
Grants
NIAID NIH HHS · P01 AI35296 · United States
NIAID NIH HHS · R01 AI088209 · United States
NIAID NIH HHS · R37 AI39560 · United States
NIAID NIH HHS · P01 AI035296 · United States
NIAID NIH HHS · R37 AI039560 · United States
NIAID NIH HHS · R01 AI75168 · United States
NIAID NIH HHS · R37 AI38903 · United States
NIAID NIH HHS · R37 AI038903 · United States
External Links
PubMed source DOI: 10.1038/ni.2938 PMC Full Text View journal details
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