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PMID: 2513485 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Inhibition by phospholipids of the interaction between R-ras, rho, and their GTPase-activating proteins.

Molecular and cellular biology ·Vol. 9 ·No. 11 ·1989-11-00 ·Pages 5260-4

Tsai MH, Hall A, Stacey DW

Abstract

Certain lipids were found to inhibit the interaction between rho and R-ras proteins and their respective GTPase-activating proteins (GAP). Inhibitory lipids were similar for each protein but differed significantly from those previously found to inhibit the interaction between ras protein and GAP activity. These data raise the possibility that ras and related proteins are controlled biologically by interactions between lipids and GAP molecules.

MeSH Terms
GTP Phosphohydrolases/metabolism GTP-Binding Proteins/metabolism GTPase-Activating Proteins Kinetics Membrane Proteins/metabolism Phospholipids/metabolism Proteins/metabolism Proto-Oncogene Proteins/metabolism Proto-Oncogene Proteins p21(ras) ras GTPase-Activating Proteins rhoB GTP-Binding Protein
Chemicals
GTPase-Activating Proteins Membrane Proteins Phospholipids Proteins Proto-Oncogene Proteins ras GTPase-Activating Proteins GTP Phosphohydrolases GTP-Binding Proteins Proto-Oncogene Proteins p21(ras) rhoB GTP-Binding Protein
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Tsai M H
Department of Molecular Biology, Cleveland Clinic Foundation, Ohio 44195.
Hall A
Stacey D W
References (19)
19 references, click to expand
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Article Info
Journal
Molecular and cellular biology
Abbr.
Mol Cell Biol
ISSN
0270-7306
DOI
10.1128/mcb.9.11.5260-5264.1989
Published
1989-11-00
Pages
5260-4
Language
English
Region
United States
NLM ID
8109087
PMCID
PMC363684
Subset
IM
External Links
PubMed source DOI: 10.1128/mcb.9.11.5260-5264.1989 PMC Full Text View journal details
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