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题目:: Out of the F-box: reawakening the pancreas.
作者:: Seifert(Bryce A),Xiong(Yue)
状态:: 发布时间2014-08-09 , 更新时间 2016-11-25
期刊:: Cell Stem Cell
摘要:: The adult pancreas lacks stem cells, and consequently, differentiation of pancreatic endocrine cells has been restricted to embryonic development or experimental manipulation. In this issue of Cell Stem Cell, Sancho et al. (2014) show that pancreas-specific loss of the ubiquitin ligase Fbxw7 stabilizes an endocrine-specific transcription factor, Ngn3, thus inducing in vivo β cell neogenesis.
语言:: eng
DOI:

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