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题目:: Birth weight and subsequent risk of cancer.
作者:: Spracklen(Cassandra N),Wallace(Robert B),Sealy-Jefferson(Shawnita),Robinson(Jennifer G),Freudenheim(Jo L),Wellons(Melissa F),Saftlas(Audrey F),Snetselaar(Linda G),Manson(JoAnn E),Hou(Lifang),Qi(Lihong),Chlebowski(Rowan T),Ryckman(Kelli K)
状态:: 发布时间2014-10-06 , 更新时间 2016-12-07
期刊:: Cancer Epidemiol
摘要:: We aimed to determine the association between self-reported birth weight and incident cancer in the Women's Health Initiative Observational Study cohort, a large multiethnic cohort of postmenopausal women.,65,850 women reported their birth weight by category (<6 lbs, 6-7 lbs 15 oz, 8-9 lbs 15 oz, and ≥10 lbs). All self-reported, incident cancers were adjudicated by study staff. We used Cox proportional hazards regression to estimate crude and adjusted hazard ratios (aHR) for associations between birth weight and: (1) all cancer sites combined, (2) gynecologic cancers, and (3) several site-specific cancer sites.,After adjustments, birth weight was positively associated with the risk of lung cancer (p=0.01), and colon cancer (p=0.04). An inverse trend was observed between birth weight and risk for leukemia (p=0.04). A significant trend was not observed with breast cancer risk (p=0.67); however, women born weighing ≥10 lbs were less likely to develop breast cancer compared to women born between 6 lbs-7 lbs 15 oz (aHR 0.77, 95% CI 0.63, 0.94).,Birth weight category appears to be significantly associated with the risk of any postmenopausal incident cancer, though the direction of the association varies by cancer type.
语言:: eng
DOI:

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