Mouse models address key concerns regarding autophagy inhibition in cancer therapy.
作者:
Amaravadi(Ravi),Debnath(Jayanta)
状态:
发布时间2014-08-05
, 更新时间 2016-10-25
期刊:
Cancer Discov
摘要:
With multiple clinical trials under way targeting autophagy against cancer, Yang and colleagues and Karsli-Uzunbas and colleagues address important concerns regarding autophagy inhibition in patients with cancer, using genetically engineered mouse models that more accurately represent the tumor biology found in human patients with pancreatic and lung cancers.