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PMID: 25053807 Published · ppublish English Journal Article Comment

RABbing cancer the wrong way.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 111 ·No. 31 ·2014-08-05 ·Pages 11230-1

Khade PK, Giannakakou P

Abstract

暂无摘要

MeSH Terms
Animals Basic Helix-Loop-Helix Transcription Factors/metabolism Breast Neoplasms/metabolism,pathology Exosomes/metabolism Female Humans Hypoxia-Inducible Factor 1, alpha Subunit/metabolism rab GTP-Binding Proteins/metabolism
Chemicals
Basic Helix-Loop-Helix Transcription Factors HIF1A protein, human Hypoxia-Inducible Factor 1, alpha Subunit RAB22A protein, human endothelial PAS domain-containing protein 1 rab GTP-Binding Proteins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Khade Prashant K
Department of Medicine, Division of Hematology and Medical Oncology, Weill Cornell Medical College and the Weill Cornell Cancer Center, New York, NY 10021.
Giannakakou Paraskevi
Department of Medicine, Division of Hematology and Medical Oncology, Weill Cornell Medical College and the Weill Cornell Cancer Center, New York, NY 10021 pag2015@med.cornell.edu.
References (19)
19 references, click to expand
  1. Targeting HIF-1 for cancer therapy.
    Nat Rev Cancer. 2003 Oct;3(10):721-32 PMID: 13130303
  2. Hypoxia-inducible factors and RAB22A mediate formation of microvesicles that stimulate breast cancer invasion and metastasis.
    Proc Natl Acad Sci U S A. 2014 Aug 5;111(31):E3234-42 PMID: 24938788
  3. Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.
    Proc Natl Acad Sci U S A. 1995 Jun 6;92(12):5510-4 PMID: 7539918
  4. Hypoxia--a key regulatory factor in tumour growth.
    Nat Rev Cancer. 2002 Jan;2(1):38-47 PMID: 11902584
  5. Modeling tissue morphogenesis and cancer in 3D.
    Cell. 2007 Aug 24;130(4):601-10 PMID: 17719539
  6. Essential role for TrpC5-containing extracellular vesicles in breast cancer with chemotherapeutic resistance.
    Proc Natl Acad Sci U S A. 2014 Apr 29;111(17):6389-94 PMID: 24733904
  7. Drug resistance and the solid tumor microenvironment.
    J Natl Cancer Inst. 2007 Oct 3;99(19):1441-54 PMID: 17895480
  8. Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET.
    Nat Med. 2012 Jun;18(6):883-91 PMID: 22635005
  9. A perspective on cancer cell metastasis.
    Science. 2011 Mar 25;331(6024):1559-64 PMID: 21436443
  10. Microtubule-dependent endosomal sorting of clathrin-independent cargo by Hook1.
    J Cell Biol. 2013 Apr 15;201(2):233-47 PMID: 23589492
  11. The impact of O2 availability on human cancer.
    Nat Rev Cancer. 2008 Dec;8(12):967-75 PMID: 18987634
  12. Hypoxia and the extracellular matrix: drivers of tumour metastasis.
    Nat Rev Cancer. 2014 Jun;14(6):430-9 PMID: 24827502
  13. Exosomes reflect the hypoxic status of glioma cells and mediate hypoxia-dependent activation of vascular cells during tumor development.
    Proc Natl Acad Sci U S A. 2013 Apr 30;110(18):7312-7 PMID: 23589885
  14. Cancer cell-derived microvesicles induce transformation by transferring tissue transglutaminase and fibronectin to recipient cells.
    Proc Natl Acad Sci U S A. 2011 Mar 22;108(12):4852-7 PMID: 21368175
  15. Rab GTPases at a glance.
    J Cell Sci. 2007 Nov 15;120(Pt 22):3905-10 PMID: 17989088
  16. Hypoxia inducible factor pathway inhibitors as anticancer therapeutics.
    Future Med Chem. 2013 Apr;5(5):553-72 PMID: 23573973
  17. Rab GTPases as coordinators of vesicle traffic.
    Nat Rev Mol Cell Biol. 2009 Aug;10(8):513-25 PMID: 19603039
  18. Extracellular vesicles: emerging targets for cancer therapy.
    Trends Mol Med. 2014 Jul;20(7):385-93 PMID: 24703619
  19. Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells.
    Nat Cell Biol. 2008 May;10(5):619-24 PMID: 18425114
Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
1091-6490
DOI
10.1073/pnas.1410788111
Email
pag2015@med.cornell.edu
Published
2014-08-05
Epub
2014-00-22
Pages
11230-1
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC4128146
Subset
IM
Corrections
CommentOn
PMID: 24938788
External Links
PubMed source DOI: 10.1073/pnas.1410788111 PMC Full Text View journal details
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