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PMID: 2505294 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Nucleus accumbens as a substrate for the aversive stimulus effects of opiate withdrawal.

Psychopharmacology ·Vol. 98 ·No. 4 ·1989-00-00 ·Pages 530-4

Koob GF, Wall TL, Bloom FE

Abstract

Previous studies from our laboratory using methylnaloxonium, a hydrophilic antagonist, showed that opiate receptors in the region of the nucleus accumbens are important for the acute reinforcing effects of heroin in non-dependent rats. A similar increased sensitivity to the response disruptive effects of intracerebrally injected methylnaloxonium in opiate dependent rats was observed in a fixed-ratio (FR) baseline of operant behaviors. These results suggest that the same opiate receptors in the region of the nucleus accumbens important for the positive reinforcing stimulus properties of opiates may also be responsible for the response disruptive, aversive stimulus properties of opiate withdrawal. These results also suggest that the neural substrates of some aspects of dependence may be partly related to those of the reinforcing effects of opiates. In particular, it is hypothesized that "euphoria" and "dysphoria" induced by opiates may reflect opponent motivational processes operating at a cellular level within the nucleus accumbens.

MeSH Terms
Animals Conditioning, Operant/drug effects Dose-Response Relationship, Drug Injections, Intraventricular Male Morphine/administration & dosage,pharmacology Naloxone/administration & dosage,analogs & derivatives,pharmacology Nucleus Accumbens/physiology Quaternary Ammonium Compounds Rats Rats, Inbred Strains Reinforcement Schedule Reinforcement, Psychology Septal Nuclei/physiology Substance Withdrawal Syndrome/physiopathology Time Factors
Chemicals
Quaternary Ammonium Compounds Naloxone N-methylnaloxone Morphine
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Koob G F
Department of Basic and Clinical Research, Research Institute of Scripps Clinic, La Jolla, CA 92037.
Wall T L
Bloom F E
References (12)
12 references, click to expand
  1. Neuroanatomical correlates of morphine dependence.
    Science. 1972 Aug 18;177(4049):616-7 PMID: 4558902
  2. Pharmacokinetics and pharmacodynamics of subcutaneous morphine pellets in the rat.
    J Pharmacol Exp Ther. 1985 Nov;235(2):282-6 PMID: 4057070
  3. Anatomically distinct opiate receptor fields mediate reward and physical dependence.
    Science. 1984 May 4;224(4648):516-7 PMID: 6324347
  4. The relationship between pipradrol-induced responding for electrical brain stimulation, stereotyped behaviour and locomotor activity.
    Neuropharmacology. 1978 Jun;17(6):363-6 PMID: 27732
  5. Brain sites of precipitated abstinence in morphine-dependent rats.
    J Pharmacol Exp Ther. 1973 Apr;185(1):108-15 PMID: 4735025
  6. Simultaneous quantitative assessment of morphine tolerance and physical dependence.
    J Pharmacol Exp Ther. 1969 May;167(1):1-8 PMID: 5814495
  7. The combined use of clonidine and naltrexone as a rapid, safe, and effective treatment of abrupt withdrawal from methadone.
    Am J Psychiatry. 1986 Jul;143(7):831-7 PMID: 3717421
  8. Effects of intracerebroventricular administration of methyl naloxonium chloride on heroin self-administration in the rat.
    Pharmacol Biochem Behav. 1985 Sep;23(3):495-8 PMID: 4048243
  9. A comparison of the effects of naloxone upon body weight loss and suppression of fixed-ratio operant behavior in morphine-dependent rats.
    J Pharmacol Exp Ther. 1977 Apr;201(1):44-54 PMID: 557543
  10. Blockade of nucleus accumbens opiate receptors attenuates intravenous heroin reward in the rat.
    Psychopharmacology (Berl). 1985;86(1-2):37-42 PMID: 2991967
  11. Clonidine antagonizes naloxone-induced suppression of conditioned behavior and body weight loss in morphine-dependent rats.
    Pharmacol Biochem Behav. 1978 Sep;9(3):319-25 PMID: 568805
  12. Effects of opiate antagonists and their quaternary derivatives on heroin self-administration in the rat.
    J Pharmacol Exp Ther. 1984 May;229(2):481-6 PMID: 6716270
Article Info
Journal
Psychopharmacology
Abbr.
Psychopharmacology (Berl)
ISSN
0033-3158
DOI
10.1007/BF00441954
Published
1989-00-00
Pages
530-4
Language
English
Region
Germany
NLM ID
7608025
Subset
IM
Grants
NIDA NIH HHS · DA 04043 · United States
External Links
PubMed source DOI: 10.1007/BF00441954 View journal details
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