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PMID: 25016 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S. Review

The nature of the renal response to chronic disorders of acid-base equilibrium.

The American journal of medicine ·Vol. 64 ·No. 3 ·1978-03-00 ·Pages 417-28

Schwartz WB, Cohen JJ

Abstract

The rate of acid excretion by the kidney appears to be determined by factors regulating the site and the rate of sodium reabsorption, rather than by a homeostatic mechanism that responds to systemic pH. This hypothesis, although unconventional, is supported by much experimental evidence, and it accounts for a wide variety of clinical and physiologic findings that heretofore have been difficult or impossible to explain.

MeSH Terms

Absorption Acid-Base Imbalance/physiopathology,urine Acidosis Alkalosis/metabolism Ammonia/metabolism Animals Bicarbonates/metabolism Carbon Dioxide/blood Cations/metabolism Chronic Disease Dogs Homeostasis Humans Hydrogen-Ion Concentration Hypercapnia/metabolism Kidney/physiopathology Kidney Tubules/physiopathology Minerals Nephrons/physiopathology Sodium/metabolism Vasopressins/metabolism

Chemicals

Bicarbonates Cations Minerals Vasopressins Carbon Dioxide Ammonia Sodium

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Schwartz W B

Cohen J J

Article Info

Journal

The American journal of medicine

Abbr.

Am J Med

ISSN

0002-9343

DOI

10.1016/0002-9343(78)90227-9

Published

1978-03-00

Pages

417-28

Language

English

Region

United States

NLM ID

0267200

Subset

External Links

PubMed source DOI: 10.1016/0002-9343(78)90227-9 View journal details

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The nature of the renal response to chronic disorders of acid-base equilibrium.

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