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PMID: 2498095 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Postantibiotic and bactericidal effect of imipenem against Pseudomonas aeruginosa.

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology ·Vol. 8 ·No. 2 ·1989-02-00 ·Pages 136-41

Odenholt I, Isaksson B, Nilsson L, Cars O

Abstract

The postantibiotic effect of imipenem on Pseudomonas aeruginosa was studied at different inocula using one ATCC strain and four clinical isolates. The postantibiotic effect was measured using two different methods: viable counts and bioluminescence assay of intracellular bacterial ATP. The postantibiotic effect could be demonstrated with both methods (viable counts 1-2 h, ATP assay 3-5 h) for all strains at an inoculum of 10(6) CFU/ml. When the inoculum was raised to 10(8) CFU/ml, no postantibiotic effect could be observed with either method using routine growth conditions. This disappearance of the postantibiotic effect coincided with a loss of bactericidal effect of imipenem when high inocula were used. Improved oxygenation of the cultures restored the bactericidal and postantibiotic effects of imipenem at high inocula.

MeSH Terms
Dose-Response Relationship, Drug Humans Imipenem/administration & dosage,analysis,pharmacology Microbial Sensitivity Tests Pseudomonas aeruginosa/drug effects,growth & development
Chemicals
Imipenem
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Odenholt I
Department of Infectious Diseases, Uppsala University, Sweden.
Isaksson B
Nilsson L
Cars O
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Article Info
Journal
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology
Abbr.
Eur J Clin Microbiol Infect Dis
ISSN
0934-9723
DOI
10.1007/BF01963897
Published
1989-02-00
Pages
136-41
Language
English
Region
Germany
NLM ID
8804297
Subset
IM
External Links
PubMed source DOI: 10.1007/BF01963897 View journal details
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