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题目:: Influence of race on microsatellite instability and CD8+ T cell infiltration in colon cancer.
作者:: Carethers(John M),Murali(Bhavya),Yang(Bing),Doctolero(Ryan T),Tajima(Akihiro),Basa(Ranor),Smith(E Julieta),Lee(Monte),Janke(Ryan),Ngo(Tina),Tejada(Ruth),Ji(Ming),Kinseth(Matthew),Cabrera(Betty L),Miyai(Katsumi),Keku(Temitope O),Martin(Christopher F),Galanko(Joseph A),Sandler(Robert S),McGuire(Kathleen L)
状态:: 发布时间2014-06-24 , 更新时间 2016-10-19
期刊:: PLoS One
摘要:: African American patients with colorectal cancer show higher mortality than their Caucasian counterparts. Biology might play a partial role, and prior studies suggest a higher prevalence for microsatellite instability (MSI) among cancers from African Americans, albeit patients with MSI cancers have improved survival over patients with non-MSI cancers, counter to the outcome observed for African American patients. CD8+ T cell infiltration of colon cancer is postively correlated with MSI tumors, and is also related to improved outcome. Here, we utilized a 503-person, population-based colon cancer cohort comprising 45% African Americans to determine, under blinded conditions from all epidemiological data, the prevalence of MSI and associated CD8+ T cell infiltration within the cancers. Among Caucasian cancers, 14% were MSI, whereas African American cancers demonstrated 7% MSI (P = 0.009). Clinically, MSI cancers between races were similar; among microsatellite stable cancers, African American patients were younger, female, and with proximal cancers. CD8+ T cells were higher in MSI cancers (88.0 vs 30.4/hpf, P<0.0001), but was not different between races. Utilizing this population-based cohort, African American cancers show half the MSI prevalence of Caucasians without change in CD8+ T cell infiltration which may contribute towards their higher mortality from colon cancer.
语言:: eng
DOI:

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