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题目:: Interaction between endometrium epithelial cells (SNG-M) and teratocarcinoma cells (HT-H) differentiated into trophoblast.
作者:: Fukuda(M N)
状态:: 发布时间1991-02-21 , 更新时间 2012-05-31
期刊:: Hum Cell
摘要:: Many of the human teratocarcinoma cell lines resemble cells of preblastocyst to trophectoderm. The use of these cell lines is, however, limited since they differentiate poorly in vitro. HT-H cell line might be useful as it differentiates into syncytiotrophoblast. Because syncytiotrophoblast of the blastocyst are the cells which attach to the maternal endometrium epithelium during implantation, HT-H cells were examined for their adhesion to SNG-M cells, which feature exhibit cells of endometrium epithelium. Differentiated HT-H cells attached to SNG-M cells, and between these two cells desmosomes and adherent junctions were developed. Undifferentiated HT-H cells did not directly attach to SNG-M cells. Cell-to-cell adhesions are often mediated by the homophilic adhesion molecules present in both cells. As the first step in the investigation of adhesion between SNG-M and HT-H cells, we examined adhesion between SNG-M cells themselves. Calcium had no effect on aggregation of SNG-M cells, which may exclude the involvement of cadherin type molecule in this system. Development of monoclonal antibodies that bind to the cell surface and inhibit aggregation of SNG-M cells, and SNG-M to HT-H cells will allow us to identify the adhesion molecule(s) involved in ovum implantation in utero.
语言:: eng
DOI:

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