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题目:: Therapy-related B lymphoblastic leukemia with t(4;11)(q21;q23)/AF4-MLL in a patient with mantle cell lymphoma after recent aggressive chemotherapy: a unique case report.
作者:: Holdener(Stephanie L),Harrington(Lacey),Nguyen(Johnny),Horna(Pedro),Sagatys(Elizabeth),Shah(Bijal),Zhang(Ling)
状态:: 发布时间2014-05-12 , 更新时间 2016-11-25
期刊:: Int J Clin Exp Pathol
摘要:: Mantle cell lymphoma (MCL) is a mature B-cell lymphoma associated with the hallmark translocation t(11;14)(q13;32), which involves the cyclin D1 (CCND1) and immunoglobin heavy chain (IgH) genes. It may transform to a more aggressive blastoid or pleomorphic variant, with or without acquisition of chromosomal abnormalities. MCL could also present with a leukemic phase with marked lymphocytosis. A literature search did not reveal any prior reports of MCL transforming to or followed by a B-cell lymphoblastic leukemia (B-ALL).
语言:: eng
DOI:

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