| GeneLibs

题目:: Predictive utility of cyclo-oxygenase-2 expression by colon and rectal cancer.
作者:: Lobo Prabhu(Kristel C),Vu(Lan),Chan(Simon K),Phang(Terry),Gown(Allen),Jones(Steven J),Wiseman(Sam M)
状态:: 发布时间2014-05-05 , 更新时间 2015-11-19
期刊:: Am J Surg
摘要:: Cyclo-oxygenase-2 (COX-2), an inducible enzyme expressed in areas of inflammation, is a target of interest for colorectal cancer therapy. Currently, the predictive significance of COX-2 in colorectal cancer remains unclear.,Tissue microarrays were constructed using 118 colon cancer and 85 rectal cancer specimens; 44 synchronous metastatic colon cancer and 22 rectal cancer lymph nodes were also evaluated. COX-2 expression was assessed by immunohistochemistry. Univariate analysis was used to determine the predictive significance of clinicopathologic variables. Overall survival, disease-specific survival, and disease-free survival were the main outcomes examined.,COX-2 was found to be expressed in 93% of colon cancers and 87% of rectal cancers. Decreased COX-2 expression was related to decreased disease-specific survival (P = .016) and decreased disease-free survival (P = .019) in the rectal cancer cohort but not in the colon cancer cohort.,COX-2 expression has predictive utility for management of rectal but not colon cancer.
语言:: eng
DOI:: 10.1016/j.amjsurg.2013.12.019

文献库文献相关信息