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PMID: 2479146 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S. Review

The impact of postsynaptic calcium on synaptic transmission--its role in long-term potentiation.

Trends in neurosciences ·Vol. 12 ·No. 11 ·1989-11-00 ·Pages 444-50

Malenka RC, Kauer JA, Perkel DJ, Nicoll RA

Abstract

Recent studies have gone a long way to explain the steps involved in generating long-term potentiation (LTP). This review focuses on the triggering role of postsynaptic calcium, the sequence of events which might be initiated by calcium, and where the persistent change may ultimately occur during LTP.

MeSH Terms
Animals Calcium/physiology Receptors, N-Methyl-D-Aspartate Receptors, Neurotransmitter/physiology Synapses/physiology Synaptic Membranes/physiology Synaptic Transmission/physiology Time Factors
Chemicals
Receptors, N-Methyl-D-Aspartate Receptors, Neurotransmitter Calcium
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Malenka R C
Kauer J A
Perkel D J
Nicoll R A
Article Info
Journal
Trends in neurosciences
Abbr.
Trends Neurosci
ISSN
0166-2236
DOI
10.1016/0166-2236(89)90094-5
Published
1989-11-00
Pages
444-50
Language
English
Region
England
NLM ID
7808616
Subset
IM
Grants
NIMH NIH HHS · MH00437 · United States
PHS HHS · N524205 · United States
External Links
PubMed source DOI: 10.1016/0166-2236(89)90094-5 View journal details
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