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题目:: Prospective population-based study of the association between serum 25-hydroxyvitamin-D levels and the incidence of specific types of cancer.
作者:: Skaaby(Tea),Husemoen(Lise Lotte Nystrup),Thuesen(Betina Heinsbæk),Pisinger(Charlotta),Jørgensen(Torben),Roswall(Nina),Larsen(Sofus Christian),Linneberg(Allan)
状态:: 发布时间2014-07-03 , 更新时间 2014-07-03
期刊:: Cancer Epidemiol Biomarkers Prev
摘要:: Observational studies have suggested an inverse association between vitamin D status and cancer. We investigated the prospective associations between vitamin D status and the total and specific type of cancer in three cohorts from the general Danish population.,A total of 12,204 individuals 18 to 71 years old were included. The level of 25-hydroxyvitamin D was measured at baseline, and information about cancer was obtained from the Danish Cancer Registry.,During the 11.3-year median follow-up time, there were 1,248 incident cancers. HRs [95% confidence intervals (CI)] per 10 nmol/L higher baseline vitamin D level were: for all cancers (HR = 1.02; 95% CI, 0.99-1.04), all cancers excluding non-melanoma skin cancer, NMSC (HR = 1.00; 95% CI, 0.97-1.03), head and neck cancer (HR = 0.97; 95% CI, 0.84-1.12), colorectal cancer (HR = 0.95; 95% CI, 0.88-1.02), cancer of bronchus and lung (HR = 0.98; 95% CI, 0.91-1.05), breast cancer (HR = 1.02; 95% CI, 0.96-1.09), cancer of the uterus (HR = 1.10; 95% CI, 0.95-1.27), prostate cancer (HR = 1.00; 95% CI, 0.93-1.08), cancer of the urinary organs (HR = 1.01; 95% CI, 0.90-1.14), NMSC (HR = 1.06; 95% CI, 1.02-1.10), and malignant melanoma (HR = 1.06; 95% CI, 0.95-1.17).,Apart from a significantly higher risk for NMSC with higher vitamin D status, we found no statistically significant associations between vitamin D status and total or specific cancers.,Our results do not indicate that there is an impact of vitamin D on total cancer incidence.
语言:: eng
DOI:: 10.1158/1055-9965.EPI-14-0007

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