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PMID: 24781194 Published · ppublish English Journal Article Review

Regulatory T cells and their roles in immune dysregulation and allergy.

Immunologic research ·Vol. 58 ·No. 2-3 ·2014-05-00 ·Pages 358-68

Pellerin L, Jenks JA, Bégin P, Bacchetta R, Nadeau KC

Abstract

The main function of the immune system is to fight off potential infections, but also to maintain its activity below a level that would trigger self-reactivity. Regulatory T cells (Tregs) such as forkhead box P3(+) (FOXP3) Tregs and type 1 regulatory T cells (Tr1) play an essential role in this active process, using several distinct suppressive mechanisms. A wide range of pathologies have been associated with altered Treg cell function. This is best exemplified by the impact of mutations of genes essential for Treg function and the associated autoimmune syndromes. This review summarizes the main features of different subtypes of Tregs and focuses on the clinical implications of their altered function in human studies. More specifically, we discuss abnormalities affecting FOXP3(+) Tregs and Tr1 cells that will lead to autoimmune manifestations and/or allergic reactions, and the potential therapeutic use of Tregs.

MeSH Terms
Animals Anti-Allergic Agents/pharmacology,therapeutic use Humans Hypersensitivity/genetics,immunology,metabolism,therapy Immunomodulation/drug effects Immunotherapy Phenotype T-Lymphocyte Subsets/drug effects,immunology,metabolism T-Lymphocytes, Regulatory/drug effects,immunology,metabolism
Chemicals
Anti-Allergic Agents
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Pellerin Laurence
Division of Pediatric Immunology and Allergy, Stanford University, Stanford, CA, 94305, USA.
Jenks Jennifer A
Bégin Philippe
Bacchetta Rosa
Nadeau Kari C
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Article Info
Journal
Immunologic research
Abbr.
Immunol Res
ISSN
1559-0755
DOI
10.1007/s12026-014-8512-5
Published
2014-05-00
Pages
358-68
Language
English
Region
United States
NLM ID
8611087
PMCID
PMC4161462
Subset
IM
Grants
NIEHS NIH HHS · R21 ES022153 · United States
External Links
PubMed source DOI: 10.1007/s12026-014-8512-5 PMC Full Text View journal details
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