| GeneLibs

题目:: Exploring the function of cell shape and size during mitosis.
作者:: Cadart(Clotilde),Zlotek-Zlotkiewicz(Ewa),Le Berre(Maël),Piel(Matthieu),Matthews(Helen K)
状态:: 发布时间2014-04-30 , 更新时间 2014-04-30
期刊:: Dev Cell
摘要:: Dividing cells almost always adopt a spherical shape. This is true of most eukaryotic cells lacking a rigid cell wall and is observed in tissue culture and single-celled organisms, as well as in cells dividing inside tissues. While the mechanisms underlying this shape change are now well described, the functional importance of the spherical mitotic cell for the success of cell division has been thus far scarcely addressed. Here we discuss how mitotic rounding contributes to spindle assembly and positioning, as well as the potential consequences of abnormal mitotic cell shape and size on chromosome segregation, tissue growth, and cancer.
语言:: eng
DOI:: 10.1016/j.devcel.2014.04.009

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