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PMID: 2476268 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Coordinate expansion of 'fetal type' lymphocytes (TCR gamma delta+T and CD5+B) in rheumatoid arthritis and primary Sjögren's syndrome.

Clinical and experimental immunology ·Vol. 77 ·No. 2 ·1989-08-00 ·Pages 175-8

Brennan F, Plater-Zyberk C, Maini RN, Feldmann M

Abstract

In the blood of 10 patients with rheumatoid arthritis (RA), the number of TCR gamma delta+T cells and CD5+B cells was 5.5% +/- 4.38 and 34.3% +/- 20.62 (mean +/- s.d.), respectively. In 12 patients with primary Sjögren's syndrome (SS) the mean +/- s.d. of these T and B cell subpopulations was 4.75% +/- 3.85 and 38.75% +/- 22.68. These values were significantly increased as compared with the circulating T and B cells from 22 healthy subjects in whom TCR gamma delta+T cells were 2.09 +/- 1.01 (P less than 0.001 for RA; P less than 0.004 for SS) and CD5+B cells were 18.09% +/- 4.47 (P less than 0.001 for RA and SS). This increase was not influenced by disease activity. Furthermore, there was a marked correlation (P less than 0.001) between the levels of TCR gamma delta +T cells and CD5+B cells. This novel finding of coordinate elevated levels of lymphocytes with fetal phenotypes in RA and primary SS suggests an immunological imbalance that may have implications in these diseases.

MeSH Terms
Antigens, Differentiation/analysis Arthritis, Rheumatoid/immunology B-Lymphocytes/immunology CD5 Antigens Humans Receptors, Antigen, T-Cell/analysis Receptors, Antigen, T-Cell, gamma-delta Sjogren's Syndrome/immunology T-Lymphocytes/immunology
Chemicals
Antigens, Differentiation CD5 Antigens Receptors, Antigen, T-Cell Receptors, Antigen, T-Cell, gamma-delta
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Brennan F
Charing Cross Sunley Research Centre, Hammersmith, London, England.
Plater-Zyberk C
Maini R N
Feldmann M
References (21)
21 references, click to expand
  1. Immunochemical proof that a novel rearranging gene encodes the T cell receptor delta subunit.
    Science. 1987 Oct 30;238(4827):682-4 PMID: 3672118
  2. A novel subset of human lymphocytes with a T cell receptor-gamma complex.
    J Exp Med. 1987 Oct 1;166(4):1192-7 PMID: 2443600
  3. B cells expressing CD5 are increased in Sjögren's syndrome.
    Arthritis Rheum. 1988 May;31(5):642-7 PMID: 3259883
  4. Predominant expression of circulating CD3+ lymphocytes bearing gamma T cell receptor in a prolonged immunodeficiency after allogeneic bone marrow transplantation.
    J Clin Invest. 1988 Sep;82(3):755-61 PMID: 3047169
  5. Mechanism of immune complex-mediated damage: induction of interleukin 1 by immune complexes and synergy with interferon-gamma and tumor necrosis factor-alpha.
    Eur J Immunol. 1989 Jan;19(1):189-92 PMID: 2493383
  6. Phenotypic and functional features of CD5+ B lymphocytes in rheumatoid arthritis.
    Scand J Rheumatol Suppl. 1988;75:76-83 PMID: 2467354
  7. T cells expressing gamma delta chain receptors in rheumatoid arthritis.
    J Autoimmun. 1988 Aug;1(4):319-26 PMID: 2978114
  8. DIAGNOSTIC criteria for rheumatoid arthritis: 1958 revision by a committee of the American Rheumatism Association.
    Ann Rheum Dis. 1959 Mar;18(1):49-51; French transl 51-2; Spanish transl 52-3 PMID: 13650459
  9. Isolation and partial characterization of a novel subset of human T lymphocytes defined by monoclonal antibodies.
    Immunology. 1982 Oct;47(2):313-20 PMID: 6749661
  10. Somatic mutation of the T15 heavy chain gives rise to an antibody with autoantibody specificity.
    Proc Natl Acad Sci U S A. 1984 Sep;81(18):5841-4 PMID: 6435121
  11. Human B cell development. II. Subpopulations in the human fetus.
    J Immunol. 1985 Mar;134(3):1531-8 PMID: 3871452
  12. Phenotype of recovering lymphoid cell populations after marrow transplantation.
    J Exp Med. 1985 Jun 1;161(6):1483-502 PMID: 3159819
  13. A rheumatoid arthritis B cell subset expresses a phenotype similar to that in chronic lymphocytic leukemia.
    Arthritis Rheum. 1985 Sep;28(9):971-6 PMID: 3899124
  14. Leu-1+ (CD5+) B cells. A major lymphoid subpopulation in human fetal spleen: phenotypic and functional studies.
    J Immunol. 1986 Jan;136(2):505-10 PMID: 2934473
  15. Human T-cell gamma genes contain N segments and have marked junctional variability.
    Nature. 1986 Jul 10-16;322(6075):184-7 PMID: 3453106
  16. A T-cell receptor gamma/CD3 complex found on cloned functional lymphocytes.
    Nature. 1987 Feb 19-25;325(6106):683-8 PMID: 3102966
  17. Two forms of the T-cell receptor gamma protein found on peripheral blood cytotoxic T lymphocytes.
    Nature. 1987 Feb 19-25;325(6106):689-94 PMID: 3102967
  18. A gamma-chain complex forms a functional receptor on cloned human lymphocytes with natural killer-like activity.
    Nature. 1987 Feb 19-25;325(6106):723-6 PMID: 3102968
  19. The T cell antigen receptor complex expressed on normal peripheral blood CD4-, CD8- T lymphocytes. A CD3-associated disulfide-linked gamma chain heterodimer.
    J Exp Med. 1987 Apr 1;165(4):1076-94 PMID: 2435832
  20. The unfolding story of T cell receptor gamma.
    FASEB J. 1987 Aug;1(2):103-9 PMID: 2956146
  21. Autoimmunity in rheumatoid arthritis. An approach via a study of B lymphocytes.
    Rheum Dis Clin North Am. 1987 Aug;13(2):319-38 PMID: 3321214
Article Info
Journal
Clinical and experimental immunology
Abbr.
Clin Exp Immunol
ISSN
0009-9104
Published
1989-08-00
Pages
175-8
Language
English
Region
England
NLM ID
0057202
PMCID
PMC1541989
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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