Microbial learning lessons: SFB educate the immune system.

Immunity ·Vol. 40 ·No. 4 ·2014-04-17 ·Pages 457-9

Lee YK, Mazmanian SK

Abstract

Segmented filamentous bacteria (SFB) contribute to immune-system maturation. In this issue of Immunity, Goto et al. (2014) and Lécuyer et al. (2014) provide evidence for how SFB induce antigen-specific T helper 17 cells and promote development of adaptive immunity at discrete mucosal sites.

MeSH Terms

Animals Antigens, Bacterial/immunology Clostridium/immunology Clostridium Infections/immunology Dendritic Cells/immunology Escherichia coli/immunology Escherichia coli Infections/immunology Histocompatibility Antigens Class II/metabolism Immunoglobulin A/metabolism Intestines/immunology Lymphocytes/immunology Plasma Cells/immunology Th17 Cells/immunology

Chemicals

Antigens, Bacterial Histocompatibility Antigens Class II Immunoglobulin A

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Lee Yun Kyung

Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.

Mazmanian Sarkis K

Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA. Electronic address: sarkis@caltech.edu.

Article Info

Journal

Immunity

Abbr.

Immunity

ISSN

1097-4180

DOI

10.1016/j.immuni.2014.04.002

sarkis@caltech.edu

Published

2014-04-17

Pages

457-9

Language

English

Region

United States

NLM ID

9432918

Subset

Corrections

CommentOn

PMID: 24684957

CommentOn

PMID: 24745335

External Links

PubMed source DOI: 10.1016/j.immuni.2014.04.002 View journal details

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