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PMID: 2472845 Published · ppublish English Journal Article

Evidence that the hypertrophic action of clenbuterol on denervated rat muscle is not propranolol-sensitive.

British journal of pharmacology ·Vol. 96 ·No. 4 ·1989-04-00 ·Pages 817-22

Maltin CA, Hay SM, Delday MI, Reeds PJ, Palmer RM

Abstract

1. The effect of propranolol on the clenbuterol-induced protein anabolism in innervated and denervated soleus and plantaris muscles of the rat was studied. 2. The response to the beta-agonist, clenbuterol, in both innervated and denervated muscles, was not significantly inhibited by the beta-antagonist, propranolol. 3. The results provide further evidence to suggest that the action of clenbuterol on skeletal muscle protein accretion may not be directly mediated by beta-adrenoceptors.

MeSH Terms
Animals Clenbuterol/pharmacology DNA/biosynthesis Ethanolamines/pharmacology In Vitro Techniques Male Muscle Denervation Muscle Development Muscle Proteins/biosynthesis Muscles/anatomy & histology,drug effects Propranolol/pharmacology RNA/biosynthesis Rats
Chemicals
Ethanolamines Muscle Proteins RNA DNA Propranolol Clenbuterol
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Maltin C A
Rowett Research Institute, Bucksburn, Aberdeen.
Hay S M
Delday M I
Reeds P J
Palmer R M
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Article Info
Journal
British journal of pharmacology
Abbr.
Br J Pharmacol
ISSN
0007-1188
DOI
10.1111/j.1476-5381.1989.tb11889.x
Published
1989-04-00
Pages
817-22
Language
English
Region
England
NLM ID
7502536
PMCID
PMC1854445
Subset
IM
External Links
PubMed source DOI: 10.1111/j.1476-5381.1989.tb11889.x PMC Full Text View journal details
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