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PMID: 2470471 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Galanin inhibits dopamine secretion and activates a potassium channel in pheochromocytoma cells.

Brain research ·Vol. 485 ·No. 1 ·1989-04-17 ·Pages 199-203

de Weille JR, Fosset M, Schmid-Antomarchi H, Lazdunski M

Abstract

Galanin inhibits depolarization-induced dopamine release from chromaffin cells. In excised membrane patches, galanin induced openings of a 36 pS, inwardly rectifying potassium channel. Galanin activation of this K+ channel was blocked by pretreatment with pertussis toxin. Galanin is without effect on L-type Ca2+ channels.

MeSH Terms
Animals Dopamine/pharmacokinetics Galanin Membrane Potentials/drug effects Mice Peptides/pharmacology Pheochromocytoma Potassium Channels/drug effects,physiology Tumor Cells, Cultured/drug effects,metabolism,physiology
Chemicals
Peptides Potassium Channels Galanin Dopamine
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
de Weille J R
Centre de Biochimie du Centre National de la Recherche Scientifique, Nice France.
Fosset M
Schmid-Antomarchi H
Lazdunski M
Article Info
Journal
Brain research
Abbr.
Brain Res
ISSN
0006-8993
DOI
10.1016/0006-8993(89)90685-9
Published
1989-04-17
Pages
199-203
Language
English
Region
Netherlands
NLM ID
0045503
Subset
IM
External Links
PubMed source DOI: 10.1016/0006-8993(89)90685-9 View journal details
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