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PMID: 2467805 Published · ppublish English Journal Article

A model for gramicidin A'-phospholipid interactions in bilayers.

European biophysics journal : EBJ ·Vol. 16 ·No. 5 ·1988-00-00 ·Pages 299-306

Cornell BA, Separovic F

Abstract

A model is proposed for the effect of gramicidin A' on the order and structure of phospholipid dispersions. According to this model, the addition of gramicidin A' influences the surrounding lipids via two independent mechanisms. The first arises from a drop in surface pressure for those lipids substantially bounded by gramicidin A'. The second mechanism arises from the increase in the phospholipid headgroup spacing due to the small polar region of the polypeptide. The model provides an explanation for the currently available NMR, X-ray diffraction and Langmuir monolayer results. The model also suggests mechanisms for the ability of gramicidin A' to trigger a transition of the lipid from the lamellar to hexagonal II phase, the dependence of this transition on the lipid chain length and the formation of a lamellar phase with lysophosphatidylcholine.

MeSH Terms
Gramicidin Lipid Bilayers Models, Chemical Phospholipids
Chemicals
Lipid Bilayers Phospholipids Gramicidin
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Cornell B A
CSIRO Division of Food Processing, North Ryde, NSW, Australia.
Separovic F
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25 references, click to expand
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Article Info
Journal
European biophysics journal : EBJ
Abbr.
Eur Biophys J
ISSN
0175-7571
DOI
10.1007/BF00254066
Published
1988-00-00
Pages
299-306
Language
English
Region
Germany
NLM ID
8409413
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00254066 View journal details
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