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PMID: 2467295 Published · ppublish English Case Reports Comparative Study Journal Article

Comparison of a human T-cell lymphotropic virus type I strain from cerebrospinal fluid of a Jamaican patient with tropical spastic paraparesis with a prototype human T-cell lymphotropic virus type I.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 86 ·No. 6 ·1989-03-00 ·Pages 2021-5

Sarin PS, Rodgers-Johnson P, Sun DK, Thornton AH, Morgan OS, Gibbs WN, Mora C, McKhann G, Gajdusek DC, Gibbs CJ

Abstract

The isolation and characterization of a human T-cell lymphotropic retrovirus related to human T-cell lymphotropic virus type I (HTLV-I) from cerebrospinal fluid of a Jamaican patient with tropical spastic paraparesis is described. The virus isolate is a typical type C retrovirus as seen by electron microscopy and is related to prototype HTLV-I isolated from patients with adult T-cell leukemia but is not identical to this prototype HTLV-I as seen by restriction enzyme mapping.

MeSH Terms
Aged Cells, Cultured Cerebrospinal Fluid/microbiology DNA Restriction Enzymes DNA, Viral/analysis Deltaretrovirus Antibodies/analysis Female Fluorescent Antibody Technique Human T-lymphotropic virus 1/enzymology,genetics,isolation & purification Humans Jamaica Leukemia, T-Cell/microbiology Leukocytes, Mononuclear/microbiology Microscopy, Electron Paraparesis, Tropical Spastic/immunology,microbiology RNA-Directed DNA Polymerase/analysis
Chemicals
DNA, Viral Deltaretrovirus Antibodies RNA-Directed DNA Polymerase DNA Restriction Enzymes
Authors & Affiliations
10 authors, click to expand affiliations / ORCID
Sarin P S
Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, MD 20892.
Rodgers-Johnson P
Sun D K
Thornton A H
Morgan O S
Gibbs W N
Mora C
McKhann G
Gajdusek D C
Gibbs C J
References (19)
19 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.86.6.2021
Published
1989-03-00
Pages
2021-5
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC286838
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.86.6.2021 PMC Full Text View journal details
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