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题目:: GABAergic signaling facilitates breast cancer metastasis by promoting ERK1/2-dependent phosphorylation.
作者:: Zhang(Depu),Li(Xiaowei),Yao(Ziming),Wei(Chuanfei),Ning(Nannan),Li(Jingxin)
状态:: 发布时间2014-05-19 , 更新时间 2014-05-19
期刊:: Cancer Lett
摘要:: The present study aims to determine the role of γ-aminobutyric acid (GABA) signaling molecules in breast cancer metastasis. Our results reveal that GABAergic system exists in breast cancer cells. Both the GABA synthetic enzyme. (GAD65/67) and GABAB receptor are expressed in 4T1 mouse breast cancer cells, MCF-7 human breast cancer cells and human breast cancer tissue. Baclofen, a GABABR agonist, significantly promoted 4T1 cells invasion and migration in vitro and metastasis in vivo, an event that was attenuated by GABABR antagonist CGP55845. Baclofen-induced breast cancer metastasis was mediated by ERK1/2 pathway.
语言:: eng
DOI:: 10.1016/j.canlet.2014.03.006

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