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题目:: In vitro and in vivo antitumor evaluation of berbamine for lung cancer treatment.
作者:: Hou(Zhi-Bo),Lu(Kai-Jin),Wu(Xiao-Li),Chen(Cong),Huang(Xin-En),Yin(Hai-Tao)
状态:: 发布时间2014-03-19 , 更新时间 2014-03-19
期刊:: Asian Pac J Cancer Prev
摘要:: Lung cancer, one of the most frequently diagnosed cancers in the world, is characterized by relatively high morbidity and mortality. Berbamine (BER) has been initially reported to exert anti-proliferative effects against a series of cancers.,In this study the in vitro cytotoxicity of BER was measured by MTT assay. In vivo anti-cancer efficacy of BER was assessed in A549 xenografts.,Cytotoxicity tests showed dose-dependent cell growth inhibition effects of BER against A549 cells. Moreover, BER significantly reduced the growth of lung cancer in a dose-dependent manner in nude mice with prolonged survival time.,Therefore, BER might be in herbal medicine for cancer therapy and further efforts are needed to explore therapeutic strategies.
语言:: eng
DOI:

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