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题目:: Ex vivo converted double negative T cells suppress activated B cells.
作者:: Li(WenXia),Tian(Yue),Li(Zhao),Gao(Jie),Shi(Wen),Zhu(JiYe),Zhang(Dong)
状态:: 发布时间2014-04-30 , 更新时间 2014-04-30
期刊:: Int Immunopharmacol
摘要:: Although the ability of endogenous CD4(-)CD8(-) double negative (DN) T cells to suppress B cells has been documented, the extent to which ex vivo converted DN T cells suppress B cells activity is still being explored. The aim of this study was to determine whether and what extent ex vivo converted CD4(-)CD8(-) DN T cells suppress B cell activation and antibody production. We found that ex vivo converted DN T cells suppressed proliferation of activated B cells in a perforin and cell-cell contact dependent manner. In addition, ex vivo converted DN T cells significantly inhibited the production of IgG by stimulated B cells. This study provides evidence that ex vivo converted CD4(-)CD8(-) double negative T cells can down-regulate immune responses by suppressing B cell proliferation and IgG production, and supports efforts to develop ex vivo DN T cell therapies.
语言:: eng
DOI:: 10.1016/j.intimp.2014.02.034

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