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题目:: 14-3-3γ-Mediated transport of plakoglobin to the cell border is required for the initiation of desmosome assembly in vitro and in vivo.
作者:: Sehgal(Lalit),Mukhopadhyay(Amitabha),Rajan(Anandi),Khapare(Nileema),Sawant(Mugdha),Vishal(Sonali S),Bhatt(Khyati),Ambatipudi(Srikant),Antao(Noelle),Alam(Hunain),Gurjar(Mansa),Basu(Srikanta),Mathur(Rohit),Borde(Lalit),Hosing(Amol S),Vaidya(Milind M),Thorat(Rahul),Samaniego(Felipe),Kolthur-Seetharam(Ullas),Dalal(Sorab N)
状态:: 发布时间2014-05-16 , 更新时间 2014-05-16
期刊:: J Cell Sci
摘要:: The regulation of cell-cell adhesion is important for the processes of tissue formation and morphogenesis. Here, we report that loss of 14-3-3γ leads to a decrease in cell-cell adhesion and a defect in the transport of plakoglobin and other desmosomal proteins to the cell border in HCT116 cells and cells of the mouse testis. 14-3-3γ binds to plakoglobin in a PKCμ-dependent fashion, resulting in microtubule-dependent transport of plakoglobin to cell borders. Transport of plakoglobin to the border is dependent on the KIF5B-KLC1 complex. Knockdown of KIF5B in HCT116 cells, or in the mouse testis, results in a phenotype similar to that observed upon 14-3-3γ knockdown. Our results suggest that loss of 14-3-3γ leads to decreased desmosome formation and a decrease in cell-cell adhesion in vitro, and in the mouse testis in vivo, leading to defects in testis organization and spermatogenesis.
语言:: eng
DOI:: 10.1242/jcs.125807

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