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PMID: 24607989 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Bacterial mechanosensitive channels: progress towards an understanding of their roles in cell physiology.

Current opinion in microbiology ·Vol. 18 ·2014-04-00 ·Pages 16-22

Booth IR

Abstract

Bacterial mechanosensitive channels sense the changes in lateral tension in the bilayer of the cytoplasmic membrane generated by rapid water flow into the cell. Two major structural families are found widely distributed across bacteria and archaea: MscL and MscS. Our understanding of the mechanisms of gating has advanced rapidly through genetic analysis, structural biology and electrophysiology. It is only recently that the analysis of the physiological roles of the channels has kept pace with mechanistic studies. Recent advances have increased our understanding of the role of the channels in preventing structural perturbation during osmotic transitions and its relationship to water flow across the membrane. It is to these recent developments that this review is dedicated.

MeSH Terms
Archaea/physiology Bacterial Physiological Phenomena Cell Membrane/physiology Cell Physiological Phenomena Comprehension Mechanical Phenomena Mechanotransduction, Cellular Models, Biological
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Booth Ian R
School of Medical Sciences, University of Aberdeen, Aberdeen, AB25 2ZD, United Kingdom; Visiting Associate in Chemistry, California Institute of Technology, Pasadena, CA 91125, United States. Electronic address: i.r.booth@abdn.ac.uk.
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Article Info
Journal
Current opinion in microbiology
Abbr.
Curr Opin Microbiol
ISSN
1879-0364
DOI
10.1016/j.mib.2014.01.005
Email
i.r.booth@abdn.ac.uk
Published
2014-04-00
Epub
2014-00-06
Pages
16-22
Language
English
Region
England
NLM ID
9815056
PMCID
PMC4005912
Subset
IM
Grants
Biotechnology and Biological Sciences Research Council · BB/H017917/1 · United Kingdom
Wellcome Trust · WT092552MA · United Kingdom
External Links
PubMed source DOI: 10.1016/j.mib.2014.01.005 PMC Full Text View journal details
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