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PMID: 24604109 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

The metastasis suppressor SOX11 is an independent prognostic factor for improved survival in gastric cancer.

International journal of oncology ·Vol. 44 ·No. 5 ·2014-05-00 ·Pages 1512-20

Qu Y, Zhou C, Zhang J, Cai Q, Li J, Du T, Zhu Z, Cui X, Liu B

Abstract

SOX11 is involved in gastrulation and in malignant diseases. The aim of this study was to investigate the role of SOX11 in gastric cancer and its expression pattern and clinical significance. SOX11 overexpression cell model was used to examine in vitro and in vivo the role of SOX11 in cell growth and metastasis. Cell cycle analysis and Annexin V/PI double staining were used to investigate the effect of SOX11 on cell cycle progression and apoptosis. The expression of SOX11 in human gastric cancer was examined by immunohistochemistry. The correlation of SOX11 expression with clinicopathological characteristics and survival of patients was analyzed by Pearson's χ(2) and Kaplan-Meier analyses, respectively. Cox's proportional hazard model was employed in multivariate analysis. SOX11 overexpression did not inhibit cell growth but strongly suppressed cell migration/invasion in vitro and in vivo. We found a significant correlation between high SOX11 protein levels and Lauren's classification (intestinal type), differentiation status (high and medium), and early TNM stage. SOX11 is an independent prognostic factor for improved survival in gastric cancer patients. SOX11 was a potential tumor-suppressor and an independent positive prognostic factor in gastric cancer patients with less advanced clinicopathological features.

MeSH Terms
Adult Aged Aged, 80 and over Animals Biomarkers, Tumor/genetics,metabolism Cell Cycle Cell Differentiation Cell Line, Tumor Female Gene Expression Regulation, Neoplastic Humans Male Mice Mice, Nude Middle Aged Neoplasm Invasiveness/genetics,pathology Neoplasm Metastasis/genetics,pathology Neoplasm Staging Neoplasms, Experimental SOXC Transcription Factors/genetics,metabolism Stomach Neoplasms/genetics,pathology
Chemicals
Biomarkers, Tumor SOX11 protein, human SOXC Transcription Factors
Authors & Affiliations
9 authors, click to expand affiliations / ORCID
Qu Ying
Shanghai Key Laboratory of Gastric Neoplasms, Shanghai Institute of Digestive Surgery, Department of Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, P.R. China.
Zhou Chenfei
Shanghai Key Laboratory of Gastric Neoplasms, Shanghai Institute of Digestive Surgery, Department of Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, P.R. China.
Zhang Jianian
Shanghai Key Laboratory of Gastric Neoplasms, Shanghai Institute of Digestive Surgery, Department of Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, P.R. China.
Cai Qu
Shanghai Key Laboratory of Gastric Neoplasms, Shanghai Institute of Digestive Surgery, Department of Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, P.R. China.
Li Jianfang
Shanghai Key Laboratory of Gastric Neoplasms, Shanghai Institute of Digestive Surgery, Department of Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, P.R. China.
Du Tao
Shanghai Key Laboratory of Gastric Neoplasms, Shanghai Institute of Digestive Surgery, Department of Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, P.R. China.
Zhu Zhenggang
Shanghai Key Laboratory of Gastric Neoplasms, Shanghai Institute of Digestive Surgery, Department of Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, P.R. China.
Cui Xiaojiang
Department of Surgery, Department of Obstetrics and Gynecology, Women's Cancer Institute, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Liu Bingya
Shanghai Key Laboratory of Gastric Neoplasms, Shanghai Institute of Digestive Surgery, Department of Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, P.R. China.
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Article Info
Journal
International journal of oncology
Abbr.
Int J Oncol
ISSN
1791-2423
DOI
10.3892/ijo.2014.2328
Published
2014-05-00
Epub
2014-00-06
Pages
1512-20
Language
English
Region
Greece
NLM ID
9306042
PMCID
PMC4027874
Subset
IM
Grants
NCI NIH HHS · R01 CA151610 · United States
NCI NIH HHS · CA151610 · United States
External Links
PubMed source DOI: 10.3892/ijo.2014.2328 PMC Full Text View journal details
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