| GeneLibs

题目:: Risk of Ipsilateral and Contralateral Cancer in BRCA Mutation Carriers with Breast Cancer.
作者:: Green(Leila),Meric-Bernstam(Funda)
状态:: 发布时间2014-03-03 , 更新时间 2016-12-06
期刊:: Curr Breast Cancer Rep
摘要:: BRCA1 and BRCA2 mutation carriers with breast cancer have a high risk of ipsilateral breast cancer tumor recurrence (IBTR) and a high lifetime risk of contralateral breast cancer (CBC). The IBTR risk is significantly higher in women who elect breast conservation. Oophorectomy has a protective effect for both ipsilateral breast tumor recurrence and CBC. Patients with younger age of breast cancer onset have a significantly greater risk of CBC. Given the higher risk of IBTR and CBC, when indicated, patients with breast cancer should undergo genetic counseling early in their treatment course to assist them in their surgical decision-making. Knowledge of expected outcomes for BRCA1/2 mutation carriers following breast cancer treatment can help appropriately council patients and personalize cancer therapy.
语言:: eng
DOI:

文献库文献相关信息