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PMID: 2458784 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Morphometric evaluation of microvessels surrounding hyperplastic and neoplastic mammary lesions.

Breast cancer research and treatment ·Vol. 11 ·No. 3 ·1988-07-00 ·Pages 241-8

Ottinetti A, Sapino A

Abstract

Size and density of microvessels in close proximity to normal, hyperplastic, and in situ neoplastic mammary epithelium were evaluated with a morphometric method. Human tissue samples were obtained from breast mammoplasty or biopsy specimens with diagnosis of either epitheliosis or ductal carcinoma in situ. The mean vessel size was significantly enhanced in hyperplastic and neoplastic lesions as compared to mammoplasty specimens considered as 'normal'. On the contrary, the density of the microvessels around the epithelium was comparable in the three groups of tissues. It appears that as long as the basement membrane remains intact, sprouting of new vessels around neoplastic lesions is not manifested.

MeSH Terms
Adult Breast/blood supply,pathology Breast Neoplasms/blood supply,pathology Female Humans Hyperplasia Microcirculation/pathology Middle Aged Neovascularization, Pathologic
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Ottinetti A
Dipartimento di Scienze Biomediche ed Oncologia Umana, Università di Torino, Italia.
Sapino A
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Article Info
Journal
Breast cancer research and treatment
Abbr.
Breast Cancer Res Treat
ISSN
0167-6806
DOI
10.1007/BF01807282
Published
1988-07-00
Pages
241-8
Language
English
Region
Netherlands
NLM ID
8111104
Subset
IM
External Links
PubMed source DOI: 10.1007/BF01807282 View journal details
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