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题目:: A regulatory network of Drosophila germline stem cell self-renewal.
作者:: Yan(Dong),Neumüller(Ralph A),Buckner(Michael),Ayers(Kathleen),Li(Hua),Hu(Yanhui),Yang-Zhou(Donghui),Pan(Lei),Wang(Xiaoxi),Kelley(Colleen),Vinayagam(Arunachalam),Binari(Richard),Randklev(Sakara),Perkins(Lizabeth A),Xie(Ting),Cooley(Lynn),Perrimon(Norbert)
状态:: 发布时间2014-02-28 , 更新时间 2016-11-22
期刊:: Dev Cell
摘要:: Stem cells possess the capacity to generate two cells of distinct fate upon division: one cell retaining stem cell identity and the other cell destined to differentiate. These cell fates are established by cell-type-specific genetic networks. To comprehensively identify components of these networks, we performed a large-scale RNAi screen in Drosophila female germline stem cells (GSCs) covering ∼25% of the genome. The screen identified 366 genes that affect GSC maintenance, differentiation, or other processes involved in oogenesis. Comparison of GSC regulators with neural stem cell self-renewal factors identifies common and cell-type-specific self-renewal genes. Importantly, we identify the histone methyltransferase Set1 as a GSC-specific self-renewal factor. Loss of Set1 in neural stem cells does not affect cell fate decisions, suggesting a differential requirement of H3K4me3 in different stem cell lineages. Altogether, our study provides a resource that will help to further dissect the networks underlying stem cell self-renewal.
语言:: eng
DOI:

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