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题目:: Acetate/acetyl-CoA metabolism associated with cancer fatty acid synthesis: overview and application.
作者:: Yoshii(Yukie),Furukawa(Takako),Saga(Tsuneo),Fujibayashi(Yasuhisa)
状态:: 发布时间2014-12-01 , 更新时间 2015-11-19
期刊:: Cancer Lett
摘要:: Understanding cancer-specific metabolism is important for identifying novel targets for cancer diagnosis and therapy. Induced acetate/acetyl CoA metabolism is a notable feature that is related to fatty acid synthesis supporting tumor growth. In this review, we focused on the recent findings related to cancer acetate/acetyl CoA metabolism. We also introduce [1-¹¹C]acetate positron emission tomography (PET), which is a useful tool to visualize up-regulation of acetate/acetyl CoA metabolism in cancer, and discuss the utility of [1-¹¹C]acetate PET in cancer diagnosis and its application to personalized medicine.
语言:: eng
DOI:: 10.1016/j.canlet.2014.02.019

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