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题目:: Circulating MMP11 and specific antibody immune response in breast and prostate cancer patients.
作者:: Roscilli(Giuseppe),Cappelletti(Manuela),De Vitis(Claudia),Ciliberto(Gennaro),Di Napoli(Arianna),Ruco(Luigi),Mancini(Rita),Aurisicchio(Luigi)
状态:: 发布时间2014-02-27 , 更新时间 2015-05-15
期刊:: J Transl Med
摘要:: Tumor Associated Antigens are characterized by spontaneous immune response in cancer patients as a consequence of overexpression and epitope-presentation on MHC class I/II machinery. Matrix Metalloprotease 11 (MMP11) expression has been associated with poor prognosis for several cancer types, including breast and prostate cancer.,MMP11 expression was determined by immunoistochemistry in breast and prostate cancer samples. Circulating MMP11 protein as well as the spontaneous immune responses against MMP11 were analyzed in a set of breast and prostate cancer patients.,In plasma samples MMP11 protein was present in 5/13 breast cancer patients and in 1/12 prostate cancer patients. An antibody response was observed in 7/13 breast cancer patients and in 3/12 prostate cancer patients.,These findings further suggest MMP11 as a promising biomarker for these tumor types and a suitable target for cancer immunotherapy strategies.
语言:: eng
DOI:

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