Self-gratification yields not-so-naive T cells.

Nature immunology ·Vol. 15 ·No. 3 ·2014-03-00 ·Pages 217-9

Martin CE, Surh CD

Abstract

暂无摘要

MeSH Terms

Animals Autoantigens/immunology CD4-Positive T-Lymphocytes/immunology Humans Lymphocyte Activation/immunology Major Histocompatibility Complex/immunology Receptors, Antigen, T-Cell/immunology

Chemicals

Autoantigens Receptors, Antigen, T-Cell

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Martin Christopher E

Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA, and the Kellogg School of Science and Technology Doctoral Program in Chemical and Biological Sciences, The Scripps Research Institute, La Jolla, California, USA.

Surh Charles D

Academy of Immunology and Microbiology, Institute for Basic Science, Pohang, Republic of Korea, the Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA, and the Department of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea.

References (9)

9 references, click to expand

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T cell-positive selection uses self-ligand binding strength to optimize repertoire recognition of foreign antigens.
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CD5 expression is developmentally regulated by T cell receptor (TCR) signals and TCR avidity.
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Intrinsic CD4+ T cell sensitivity and response to a pathogen are set and sustained by avidity for thymic and peripheral complexes of self peptide and MHC.
Nat Immunol. 2014 Mar;15(3):266-74 PMID: 24487322
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Article Info

Journal

Nature immunology

Abbr.

Nat Immunol

ISSN

1529-2916

DOI

10.1038/ni.2832

Published

2014-03-00

Pages

217-9

Language

English

Region

United States

NLM ID

100941354

Subset

Corrections

CommentOn

PMID: 24487322

External Links

PubMed source DOI: 10.1038/ni.2832 View journal details

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