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PMID: 24529368 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Comment

mTORC1: turning off is just as important as turning on.

Cell ·Vol. 156 ·No. 4 ·2014-02-13 ·Pages 627-8

Benjamin D, Hall MN

Abstract

mTORC1 is activated primarily on the lysosome. Menon et al. and Demetriades et al. show that mTORC1 deactivation on the lysosome is determined by recruitment of its negative regulator, the tumor suppressor complex TSC1-TSC2. These reports highlight the importance of subcellular localization in the regulation of mTORC1.

MeSH Terms

Amino Acids/metabolism Animals Humans Insulin/metabolism Lysosomes/metabolism Mechanistic Target of Rapamycin Complex 1 Multiprotein Complexes/metabolism Signal Transduction TOR Serine-Threonine Kinases/metabolism Tuberous Sclerosis Complex 2 Protein Tumor Suppressor Proteins/metabolism

Chemicals

Amino Acids Insulin Multiprotein Complexes TSC2 protein, human Tuberous Sclerosis Complex 2 Protein Tumor Suppressor Proteins Mechanistic Target of Rapamycin Complex 1 TOR Serine-Threonine Kinases

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Benjamin Don

Biozentrum, University of Basel, CH4056 Basel, Switzerland.

Hall Michael N

Biozentrum, University of Basel, CH4056 Basel, Switzerland. Electronic address: m.hall@unibas.ch.

Article Info

Journal

Cell

Abbr.

Cell

ISSN

1097-4172

DOI

10.1016/j.cell.2014.01.057

m.hall@unibas.ch

Published

2014-02-13

Pages

627-8

Language

English

Region

United States

NLM ID

0413066

Subset

Corrections

CommentOn

PMID: 24529379

CommentOn

PMID: 24529380

External Links

PubMed source DOI: 10.1016/j.cell.2014.01.057 View journal details

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mTORC1: turning off is just as important as turning on.

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