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PMID: 2451889 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Neovascularization and tumor growth in the rabbit brain. A model for experimental studies of angiogenesis and the blood-brain barrier.

The American journal of pathology ·Vol. 131 ·No. 2 ·1988-05-00 ·Pages 361-72

Zagzag D, Brem S, Robert F

Abstract

A model for the study of tumor angiogenesis within the rabbit brain is presented. Implantation of the VX2 carcinoma provides a reproducible tumor accompanied by angiogenesis. The authors report the sequential growth, histology, tumor neovascularization, and vascular permeability of this tumor following its intracerebral implantation. Tumor angiogenesis correlates with the rapid and logarithmic intracerebral tumor growth. The proliferation of blood vessels in the tumor and the organization of tumor cells around tumor vessels are described. Breakdown of the blood-brain barrier (detected by Evans blue leakage) starts in the early stages of tumor development and becomes prominent as the tumor vasculature and size increase. This model is useful for experimental studies of angiogenesis.

MeSH Terms
Animals Blood-Brain Barrier Brain/pathology Brain Neoplasms/blood supply,pathology Cell Division Male Neovascularization, Pathologic/pathology Rabbits
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Zagzag D
Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada.
Brem S
Robert F
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Article Info
Journal
The American journal of pathology
Abbr.
Am J Pathol
ISSN
0002-9440
Published
1988-05-00
Pages
361-72
Language
English
Region
United States
NLM ID
0370502
PMCID
PMC1880604
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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