Home LiteratureArticle Details
PMID: 2451132 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

A novel potent vasoconstrictor peptide produced by vascular endothelial cells.

Nature ·Vol. 332 ·No. 6163 ·1988-03-31 ·Pages 411-5

Yanagisawa M, Kurihara H, Kimura S, Tomobe Y, Kobayashi M, Mitsui Y, Yazaki Y, Goto K, Masaki T

Abstract

An endothelium-derived 21-residue vasoconstrictor peptide, endothelin, has been isolated, and shown to be one of the most potent vasoconstrictors known. Cloning and sequencing of preproendothelin complementary DNA shows that mature endothelin is generated through an unusual proteolytic processing, and regional homologies to a group of neurotoxins suggest that endothelin is an endogenous modulator of voltage-dependent ion channels. Expression of the endothelin gene is regulated by several vasoactive agents, indicating the existence of a novel cardiovascular control system.

MeSH Terms
Amino Acid Sequence Animals Aorta Arteries/drug effects Base Sequence Calcimycin/pharmacology Cells, Cultured DNA/genetics Endothelins Endothelium, Vascular/metabolism Epinephrine/pharmacology Gene Expression Regulation/drug effects Ion Channels/drug effects Molecular Sequence Data Peptides/genetics,isolation & purification,physiology Protein Conformation Protein Precursors/metabolism Protein Processing, Post-Translational RNA, Messenger/biosynthesis Recombinant Proteins/genetics Swine Vasoconstriction/drug effects
Chemicals
Endothelins Ion Channels Peptides Protein Precursors RNA, Messenger Recombinant Proteins Calcimycin DNA Epinephrine
Authors & Affiliations
9 authors, click to expand affiliations / ORCID
Yanagisawa M
Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki, Japan.
Kurihara H
Kimura S
Tomobe Y
Kobayashi M
Mitsui Y
Yazaki Y
Goto K
Masaki T
Article Info
Journal
Nature
Abbr.
Nature
ISSN
0028-0836
DOI
10.1038/332411a0
Published
1988-03-31
Pages
411-5
Language
English
Region
England
NLM ID
0410462
Subset
IM
Databases
GENBANK
X07383
Corrections
CommentIn
PMID: 2407960
External Links
PubMed source DOI: 10.1038/332411a0 View journal details
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