Regional distant sequence homology between amylases, alpha-glucosidases and transglucanosylases.

FEBS letters ·Vol. 230 ·No. 1-2 ·1988-03-28 ·Pages 72-6

Svensson B

Abstract

Amylases possess short, conserved regions near functional side chains. Sequence comparison extends this relationship to comprise a maltase and a cyclodextrin glucanotransferase. Similarity also exists with intestinal sucrase-isomaltase and fungal glucoamylase near identified essential carboxyl groups. Homology between COOH-terminal regions of glucoamylase and cyclodextrin glucanotranserase may indicate raw-starch binding areas. It is suggested that amylases, alpha-glucosidases, and transglucanosylases acting on 1,4- and 1,6-alpha-glucosidic linkages share key structural features in the active centres.

MeSH Terms

1,4-alpha-Glucan Branching Enzyme Amino Acid Sequence Amylases Animals Bacteria/enzymology Binding Sites Drosophila melanogaster/enzymology Fungi/enzymology Glucan 1,4-alpha-Glucosidase Glucosyltransferases Glycogen Debranching Enzyme System Humans Mice Molecular Sequence Data Oligo-1,6-Glucosidase Plants/enzymology Rabbits Rats Sequence Homology, Nucleic Acid Sucrase Swine alpha-Amylases alpha-Glucosidases

Chemicals

Glycogen Debranching Enzyme System Glucosyltransferases 1,4-alpha-Glucan Branching Enzyme cyclomaltodextrin glucanotransferase 4 alpha-glucanotransferase Amylases alpha-Amylases Oligo-1,6-Glucosidase alpha-Glucosidases Glucan 1,4-alpha-Glucosidase Sucrase

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Svensson B

Department of Chemistry, Carlsberg Laboratory, Copenhagen Valby, Denmark.

Article Info

Journal

FEBS letters

Abbr.

FEBS Lett

ISSN

0014-5793

DOI

10.1016/0014-5793(88)80644-6

Published

1988-03-28

Pages

72-6

Language

English

Region

England

NLM ID

0155157

Subset

External Links

PubMed source DOI: 10.1016/0014-5793(88)80644-6 View journal details

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Regional distant sequence homology between amylases, alpha-glucosidases and transglucanosylases.

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